Asef controls vascular endothelial permeability and barrier recovery in the lung
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چکیده
منابع مشابه
Asef controls vascular endothelial permeability and barrier recovery in the lung
Increased levels of hepatocyte growth factor (HGF) in injured lungs may reflect a compensatory response to diminish acute lung injury (ALI). HGF-induced activation of Rac1 GTPase stimulates endothelial barrier protective mechanisms. This study tested the involvement of Rac-specific guanine nucleotide exchange factor Asef in HGF-induced endothelial cell (EC) cytoskeletal dynamics and barrier pro...
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Increased vascular endothelial permeability and inflammation are major pathological mechanisms of pulmonary edema and its life-threatening complication, the acute respiratory distress syndrome (ARDS). We have previously described potent protective effects of hepatocyte growth factor (HGF) against thrombin-induced hyperpermeability and identified the Rac pathway as a key mechanism of HGF-mediate...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2015
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e14-02-0725